CIAPIN1 and metastatic malignant neoplasm in the lymph nodes: Both univariate and multivariate analyses showed that primary tumour (pT3/pT4), regional lymph node metastasis (pN1), distant tumour metastasis (pM1), local recurrence (yes) and low-expression CIAPIN1 (-/+) were independent, poor prognostic factors of CRC (Table 2 and Table 3); However, age (> 75 years), gender (male), location (rectum or sigmoid), adjuvant therapy (yes) and tumour grade (> G2) were not related to the prognosis of CRC (Table 2 and Table 3).