The overall survival of patients with high or moderate CIAPIN1 expression was significantly better than those with none or weak CIAPIN1 expression, and low expression levels of CIAPIN1 associated with the tumour stage, lymph node metastasis, distant organ metastasis and local recurrence were independent, poor prognostic factors of CRC. The gene discussed is CIAPIN1; the disease is metastatic malignant neoplasm in the lymph nodes.