Sp factors have also been found to be over expressed in tumours where they contribute to the proliferative and angiogenic phenotype associated with cancer cells by regulating number of angiogenic proteins like vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGFR1, Flt-1), VEGFR2 (KDR) and the antiapoptotic gene survivin [52-55]. This evidence concerns the gene VEGFA and neoplasm.