Such mechanisms have been proposed in the context of the trafficking of CD4+ T cell to the brLNs of CCR7-deficient mice during influenza infection, the presence of CD11b+CD11c+ DCs in the mediastinal LNs of CCR7-deficient mice during the late phase of Mycobacterium tuberculosis infection, and the homing of central memory CD8+ T cells to peripheral LNs in plt/plt (CCL19 and CCL21-Ser-gene deleted) mice [31-33]. The gene discussed is ITGAM; the disease is influenza.