PPARA and fatty liver disease: In addition, the relatively higher levels of CYP2E1 expression in ethanol-exposed LE compared with ethanol-exposed FS livers may have contributed to the increased severity of steatohepatitis in LE rats because high levels of CYP2E1 promote oxidative stress and reduce fatty acid oxidation via inhibition of PPAR-α expression, and thereby enhance ethanol-induced hepatic steatosis [43].