The workup for other causes of liver disease includes IgM anti-HAV, IgM anti-HBc, HbsAg, anti-HCV, ceruloplasmin, mitochondrial antibody, ANA, SPEP, and anti-LKM which were negative/normal except for the presence of one heterozygous copy of the H63D mutation in the HFE gene and a highly positive smooth muscle antibody of 32 (>30 highly positive). This evidence concerns the gene CD40LG and liver disorder.