STAT3 and acute myeloid leukemia: In the AML study by Irish, although a subset of samples were identified in which potentiated p-Stat3/p-Stat5 signaling correlated with clinical refractoriness to chemotherapy, not all AML patients who were refractory to chemotherapy showed a potentiated p-Stat3/p-Stat5 signaling response, suggesting the role of alternate oncogenic pathways in their leukemia [5].