CXCL8 and pneumonitis: Other significant genetic variants associated with pneumonitis included six SNPs in proinflammatory genes, including IL1A, IL8, TNFRSF1B, MIF, and NOS3. Two SNPs in IL1A – rs1800587 and rs17561– are in strong linkage disequilibrium and each resulted in a more than doubling of risk with HRs of 2.90 (95% CI:1.34–6.25) and 2.51 (95% CI:1.19–5.27), respectively.