Taking into consideration that during infection gp120 is released from cells and GPN remains intracellular and that the HIV-1 proteins expressed in MVA-B-infected immature monocyte derived dendritic cells (IMDDC) induced the expression of different immunomodulatory molecules [12], it will not be surprising if the deletion of two viral genes acting as inhibitors of an inflammatory response, might have a profound effect on the shift of immune responses, with enhanced GPN over Env response. The gene discussed is ITIH4; the disease is infection.