More recently, we showed the induction of cell death with autophagic features (e.g., autophagosome formation and addition of a phosphatidylethanolamine moiety to the microtubule-associated protein 1 light chain 3 [LC3] to a faster moving LC3-II form on electrophoresis) by PGG of p53-null, PTEN-null, (high AKT) PC-3 PCa cells, which did not undergo caspase-mediated apoptosis after exposure to PGG [8]. This evidence concerns the gene TP53 and posterior cortical atrophy.