We showed for the first time that, irrespective of the p53 and androgen dependence status of the PCa cell lines, PGG exerted a rapid (within 2 hours) and potent (IC50 [half inhibitory concentration] of approximately 6 μM) inhibition of 5-bromo-2'-deoxy-uridine (BrdU) incorporation into S-phase cells. Here, TP53 is linked to posterior cortical atrophy.