However, the expression of MRP3 in normal tissues outside the CNS will not compromise the compartmental delivery of MRP3-related immunological agents within the CNS, because the optimal route for the administration of MAb-based therapeutic agents for tumors localized within the CNS is through surgically created resection cavities or saturation of an entire hemisphere by intracranial microdiffusion, called convection-enhanced delivery, to the brain tumor [48], which allows direct parenchymal infusion of therapeutics, bypassing the blood-brain barrier. The gene discussed is ABCC3; the disease is brain neoplasm.