Recent studies have shown the role of Snail and Slug as strong repressors of E-cadherin gene expression in various cancer cell lines, including esophageal adenocarcinoma, lung, breast, endometrioid adenocarcinomas hepatoma HepG2 and human extrahepatic hilar cholangiocarcinoma, thus inducing tumor malignancy[23-28]. This evidence concerns the gene SNAI1 and neoplasm.