For example, PFD suppressed Hermansky-Pudlak syndrome (HPS)-1, alveolar macrophage cytokine and chemokine secretion in vitro in a dose-dependent manner [24] PFD was found to inhibit the responder frequency of T-cell rearrangement (TCR)-stimulated CD4 cell total proliferation in vitro and in vivo, and the proliferation index of both CD4 and CD8 was reduced. This evidence concerns the gene CD8A and polyostotic fibrous dysplasia.