Although IMPDH2 knock-down or pharmacological inhibition of IMPDH2 enzyme activity did not significantly influence the chemosensitivity of wild-type osteosarcoma cells, chemoresistant IMPDH2-overexpressing Saos-2 cells were resensitized by IMPDH2 knock-down. The gene discussed is IMPDH2; the disease is osteosarcoma.