Pathway Studio 7.0 was used to find interactions among the 12 genes and 13 major lung cancer hallmarks (EGF, EGFR, KRAS, MET, RB1, TP53, E2F1, E2F2, E2F3, E2F4, E2F5, AKT1, and TNF) reported in the literature. Here, E2F1 is linked to lung carcinoma.