IGHE and inflammatory bowel disease: The increased baseline and stimulated production of pro-inflammatory cytokines by Il10−/− BMMC to both classic (e.g. IgE) and IBD-relevant (e.g. enteric bacteria) activation stimuli in vitro suggested that Il10−/− mast cells might be particularly potent in stimulating inflammatory reactions in the gut following breakdown of the mucosal barrier in vivo.