While the spontaneous production of IFN-gamma was identical in HCMV-specific CD8 cells present at the onset and at recovery of acute hepatitis B (Figure 6 C- unstimulated), 12% of HCMV specific CD8 cells present at the onset of acute hepatitis B against only 4% of the ones present at recovery produced IFN-gamma after MHC-pentamer stimulation (Figure 6 C). Here, IFNG is linked to hepatitis B virus infection.