SERPINA1 and chronic obstructive pulmonary disease: This is illustrated in Figure 2C where we plot the distribution of Pearson correlation coefficients for the 1599 mutations in the 5′ UTR of SERPINA1 (serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 1, which is 533 nucleotides in length), where the C116U SNP is associated with COPD [34].