The main findings of the present study are that FAAH-IR is associated with prostate cancer disease severity and outcome, that FAAH-IR and CB1IR give additive prognostic information at mid-range, but not high CB1IR, and that the correlation of FAAH-IR and CB1IR in the tumour, but not in the non-malignant, tissue is consistent with a local dysregulation due to a component of the tumour microenvironment. Here, FAAH is linked to prostate carcinoma.