KCNMA1 and central nervous system cancer: BK channels have been implicated in regulation of cell proliferation in a number of malignant cell lines, such as HeLa and A2780 carcinomas, MCF-7 breast cancer, PC-3 prostate cancer, as well as in 1321N1 and D54-MG human glioma lines [20], [21], [23], [24], [25].