NLRP3 and infection: Nlrp3−/− mice had a modest but statistically significantly increase in IL-6 and TNF-α cytokines at 2 weeks (p = 0.026 and p = 0.028, respectively) and 5 weeks post-infection (p = 0.004, p = 0.001, respectively), but all differences were diminished by 16 weeks post-infection.