However, although there is increasing evidence indicating that elevated oxidative damage to SOD1 proteins are present in the tissue of ALS transgenic mice [37], it is not known currently if the oxidative modification is involved in the SOD1 aggregation in vivo because a recent study showed that the SOD1 isolated from the aggregates in several SOD1 transgenic mouse lines contained primarily full-length unmodified SOD1 proteins [41]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.