POU3F1 was also proved to affect calcium flux through binding to the promoter region of PIK3C3 (MIM 602609), a member of the phosphatidylinositide 3-kinase family, and mutations in PIK3C3 have been shown to be involved in a subset bipolar disorder and schizophrenia patients [19]. This evidence concerns the gene PIK3C3 and schizophrenia.