This was consistent with the recent observation by Konnikova et al., who have shown that targeting STAT3 by siRNA induced tumor cell death, but did not kill normal astrocytes.[50] Together, these findings demonstrate that Src and STAT3 signaling plays a critical role in glioma cell survival and proliferation and that treatment of cells with dasatinib and JSI-124 results in decreased cell viability and induces apoptosis. Here, STAT3 is linked to central nervous system cancer.