VEGFA and cancer: These suggest PO would be able to suppress angiogenic processes in HT-1080 cancer cells as well as in human endothelial cells, especially considering that it has been reported that HT-1080 cell-secreted VEGF, promoted the basement membrane degradation, migration, proliferation and tube formation of endothelial cells [26], although we have not explored further on this due to our focus of study on HUVEC angiogenesis in this report.