ADPKD results from mutations in the polycystin genes PKD1 and PKD2/TRPP2 and mutations in their respective polycystin proteins, Polycystin 1 (PC1) and Polycystin 2 (PC2), both of which have been implicated as significant regulators of intracellular Ca2+ in renal tubules [4]. The gene discussed is PKD2; the disease is autosomal dominant polycystic kidney disease.