We found that the IL-1ra protein level was not changed in the hypothalamus after chronic overnutrition or after acute exercise protocols (Figure 6A); however, IL-10 protein expression was slightly increased in the hypothalamus in obese animals; both of the exercise protocols increased IL-10 expression in a similar fashion, but the induction of IL-10 expression, mediated by exercise, was higher in the hypothalamus of obese when compared to exercised lean animals (Figure 6B). This evidence concerns the gene IL10 and overnutrition.