TLR4 and Insulin resistance: Finally, in resting conditions the treatments with either IL-6 or IL-10 are able to blunt the hyperphagic response, as well as the leptin and insulin resistance, promoted by pharmacological administration of ER stress inducers (such as the drug thapsigargin, which interferes with Ca+2 balance), in both normal and genetic models of cytokine deficiency (such as toll-like receptor 4, Tlr4, deficient mice).