Detailed pathway analysis of the upregulated targets of the lost miR-15/16 family identified biological categories of pathways in cancer, endometrial cancer, transcription, melanoma, apoptosis, signaling pathways including insulin, MAPK, mTOR, VEGF, ErbB, JAK/STAT signaling, and cell-cell adhesion and cytoskeleton remodeling (see Supplemental Table 3). Here, INS is linked to cancer.