NEDD9 and neoplasm: BCAR1 is required for Src-dependent cellular transformation of murine fibroblasts [17], and conserves with NEDD9 the ability to enhance the production of matrix metalloproteases [18], enhancing tumor cell invasion of the extracellular matrix (ECM) [19], promoting mammary tumorigenesis and lung metastasis in MMTV-HER2 and other mouse models of cancer [19], [20].