Thus, our finding that the MMP1 −1607 1G/2G, MMP2 −1306 C/T, MMP2 −1575 G/A, and MMP9 Q279R polymorphisms are not associated with an increased risk for POAG or XFG does not exclude a substantial role of MMP1, MMP2, and MMP9 in the pathogenesis of POAG or XFG. The gene discussed is MMP9; the disease is open-angle glaucoma.