As the study has a statistical power of 0.80 to detect odds ratios between 1.61 and 1.68 for the allelic variants of the MMP1 −1607 1G/2G, MMP2 −1306 C/T, MMP2 −1575 G/A, and MMP9 Q279R polymorphisms in patients with POAG and odds ratios between 1.71 and 1.77 in patients with XFG, respectively, our data suggest that the investigated polymorphisms are unlikely major genetic risk factors for POAG and XFG in Caucasian patients. This evidence concerns the gene MMP2 and open-angle glaucoma.