In the present study genotypes of the functional MMP1 −1607 1G/2G, MMP2 −1306 C/T, MMP2 −1575 G/A, and MMP9 Q279R polymorphisms were determined in 322 patients with POAG, 202 patients with XFG and 248 control subjects. The gene discussed is MMP1; the disease is open-angle glaucoma.