Moreover, in breast cancer, DR4, in contrast to DR5, has been shown to be more strongly expressed in better differentiated tumors, and correlated positively with surrogate markers of a better prognosis (hormone receptor status, Bcl-2, negative nodal status), but negatively with the expression of Her2/neu and the proliferation marker Ki67 [46]. This evidence concerns the gene NR4A1 and breast carcinoma.