Similar results were also generated when we analyzed the impact of caspase-8 and DR5 combination.Higher levels of both caspase-8 and DR5 in HNSCC with no LNM (Tu−met) was significantly associated with better disease-free survival and overall survival, but was significantly correlated with poorer disease-free survival and overall survival in HNSCC with LNM (Tu+met). The gene discussed is CASP8; the disease is head and neck squamous cell carcinoma.