In contrast, in HNSCC with LNM (Tu+met), patients with higher levels of both DR5 and caspase-8 had worse overall survival and disease-free survival relative to patients with low levels of both DR5 and caspase-8 (P = 0.0270 and P = 0.0065, respectively) (Fig. 6B). This evidence concerns the gene CASP8 and head and neck squamous cell carcinoma.