In fact, one study has shown that TRAIL enhances the invasion of apoptosis-resistant pancreatic ductal adenocarcinoma cells in vitro and increases distant metastasis (e.g., liver) of pancreatic tumors in vivo[38], suggesting that activation of the DR5 signaling may facilitate metastasis under certain conditions. The gene discussed is TNFRSF10B; the disease is pancreatic ductal adenocarcinoma.