Initially, Saccone et al. [14] reported associations of multiple single nucleotide polymorphisms (SNPs) in the CHRNA5/A3/B4 gene cluster with ND, with the smallest P value of 0.00064 for rs16969968 (D398N) in exon 5 of CHRNA5. However, the significance of these results did not survive correction for multiple testing. Here, CHRNA5 is linked to Norrie disease.