BE-8 (Diaclone, Besançon, France), a fully murine monoclonal antibody against IL-6, inhibited RCC- and IL-2/IFNα-associated toxicities in preliminary reports of testing in patients with metastatic RCC (Rossi et al, 1992; Blay et al, 1997). The gene discussed is IL2; the disease is renal cell carcinoma.