CD4 and fungal infectious disease: In the immunocompromised or immunosuppressed patient, fungal infections can be severe and prompt diagnosis with appropriate treatment is essential.[17] The treatment for blastomycosis in immunodeficient patients is Amphotericin B.[18] There have recently been efforts to create a vaccine against Blastomyces dermititidis.[19] It has been shown that in immunocompetent patients CD4 T helper cells are a major component in the immune response to Blastomyces dermititidis.