TP53 and cleft palate: TP73L, known for monogenic malformation syndromes such as cleft palate [33] (suggesting a tissue-specific role), has strong sequence similarity to the tumor suppressor TP53. Its isoforms, which are created by alternative promoters and alternative splicing, have divergent abilities to transactivate p53 reporter genes and induce apoptosis [33] (suggesting a more generalized role).