TARDBP and amyotrophic lateral sclerosis: Our observation that in chick, motor neuron loss mediated by exogenous TDP-43 expression requires the integrity of the TDP-43 C-terminal section—in addition to its N-terminally localized RNA-binding function—could further point to the possibility that ALS/FTLD-linked C-terminal TDP-43 missense mutations may act through a pathway determined by inherent TDP-43 RNA-binding function.