TARDBP and amyotrophic lateral sclerosis: To analyze possible effects of TDP-43 mislocalization, we introduced a synthetic protein modeled after the major TDP-43 C-terminal fragment (TDP-43CTF) found in cytosolic aggregates of ALS/FTLD patients [3], as well as intra-cellularly mislocalized full-length TDP-43 lacking a functional nuclear localization signal (TDP-43ΔNLS).