TARDBP and amyotrophic lateral sclerosis: This is further confounded by recent studies separately reporting that either overexpression of wild type TDP-43 (TDP-43WT), or ALS/FTLD-linked TDP-43MS, or inactivating endogenous TDP-43 [10], [11], [12], [13], [14] all lead to neuron loss in vivo in different invertebrate and vertebrate models [10], [11], [12], [13], [15], [16].