An intervening sequence (IVS) 2–1 (G to A) splice site mutation occurred in one affected male and two affected females in family II in which all affected individuals had high myopia with a refractive error ranging from −7 D to −10 D. Jin and coworkers identified a mutation, ORF15+1232_ 1233delGG, in a family with XLRP. This evidence concerns the gene RPGR and myopia.