APOE and open-angle glaucoma: To date, 3 genes have been identified for POAG; myocilin (MYOC or GLC1A) [8], optineurin (OPTN or GLC1E) [9], and WD40-repeat 36 (WDR36 or GLC1G) [10], and also associated with it are a large number of genetic variants including those in apolipoprotein E (APOE) [11], optic atrophy 1 (OPA1) [12], and cytochrome P4501B1 (CYP1B1) [13].