Recent studies have indicated that somatic cells can be reprogrammed into pluripotent embryonic stem-like cells by co-expression of pluripotency stem cell markers such as Oct4, Sox2, Nanog and Lin28 [4], [5], which raises the possibility that combined expression of stem cell-associated factors and special oncogenes could also induce a undifferentiated state in cancer cells. Here, POU5F1 is linked to cancer.