JAG1 and autoimmune disease: However, network studies based on the quantitative expression levels of 20 genes in over one hundred individuals identify jagged-1 as a new therapeutic target whose differential behavior in the MScl network was not modified by immunomodulatory therapy, illustrating how network analysis can predict therapeutic targets for immune intervention and identifying the immunomodulatory properties of jagged-1, making it a new therapeutic target for MScl and other autoimmune diseases [26].