CDKN2C and Familial prostate cancer: When we compute the correlations of the probes expressions with the Normalized Shannon Entropy values of the samples, the gene that has the most negative correlations is CDKN2C (cyclin-dependent kinase inhibitor 2C - p18, inhibits CDK4 - NM_078626), which has been previously associated with the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer [68] (Spearman correlations with the Normalized Shannon Entropy range between −0.8010 and −0.7276 for all the probes for NM_078626 in this array).