As a consequence, it has been proposed that the lack of PKP1 increases keratinocyte migration [180] and loss of PKP1 expression in head and neck squamous cell carcinoma and in esophageal squamous cell carcinoma may contribute to an invasive phenotypic behaviour [171], perhaps as a consequence of the impaired recruitment of desmoplakin. Here, DSP is linked to esophageal squamous cell carcinoma.