TP53 and Familial prostate cancer: There exist several studies linking two “tumor suppressors” BRCA1 and TP53, its expression, status and mutations, to prostate cancer progression [51], [55], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466], [467], [468], [469], [470], [471], [472], [473], [474], [475], [476], [477], [478], [479], [480], [481], [482], [483], [484], [485].