Regarding the cancer types studied in this paper, one particular “measure of disorder of a system”, aneuploidy, has been observed in poorly-differentiated prostate cancer cells and it is often associated with a more agreessive phenotype [602], [603], increased PSA levels [604], [605], and correlate with Gleason score [606], [607], [608]. Here, KLK3 is linked to Familial prostate cancer.