NFKB1 and Familial prostate cancer: A putative role for NF-kappaB in prostate cancer has been reported based on the observation of the centrality of NFKB on two up- and down-regulated networks compairing prostate tumors and healthy tissue [546] and in a larger study by McDonnel et al. [547] (255 core prostate cancer tissue microarrays from 47 prostatectomy specimens).