We observe a marked increase of expression of a probe for ADA with melanoma progression while at the same time we observe a loss of expression of a probe corresponding to DPP4/CD26 (Dipeptidyl-peptidase 4, CD26, adenosine deaminase complexing protein 2), a membrane-bound, proline-specific serine protease [128] that has been attributed tumor suppressor functions [129]. The gene discussed is DPP4; the disease is melanoma.