In summary, support for a role of AHI1 in psychotic disorder was obtained in the sample from Valencia (East Spain), in which two SNPs located upstream from AHI1 gene (SNP14-rs7750586 and SNP27-rs911507) were significantly associated with schizophrenia, with a moderate effect size (Odds Ratios (ORs) were 1.53 and 1.34, respectively). This evidence concerns the gene AHI1 and schizophrenia.