It is well established that the expression of fetal genes, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and β-myosin heavy chain (βMHC), is reactivated in a variety of cardiac pathological conditions, such as ischemia, heart failure, hypertrophy and atrophy [15]. The gene discussed is NPPB; the disease is ischemia.