PARP1 and hyperlipidemia: On the other hand, the lack of effect of NIC, a more potent PARP-1 inhibitor than TAU on hyperlipidemia by STZ suggests that PARP-1 inhibitory potency is not a reliable predictor of the type and extent of the effect that a PARP inhibitor may have on the plasma lipids associated with diabetic hyperlipidemia.