In more than 1,800 patients studied over 16 to 26 weeks, pioglitazone monotherapy was associated with increases of +0.9 to +2.6 kg as doses were uptitrated from 15-45 mg and increases of +2.3 to +4.1 kg in combination with insulin across the same dosing range in patients with type 2 diabetes [58,59]. The gene discussed is INS; the disease is type 2 diabetes mellitus.