In a 4-week study of 203 patients with type 2 diabetes currently receiving insulin therapy, pramlintide was associated with reductions in TC (-4.7 to -10.5 mg/dL), LDL-C (-4.4 to -.75 mg/dL), and TG (-9.0 to -66.4 mg/dL), with the greatest reductions seen when the dosage was increased from 120 to 240 mg/day. The gene discussed is INS; the disease is type 2 diabetes mellitus.