UC patients with the polymorphisms TLR1-R80T and TLR2-R753Q appear to exhibit increased risk to develop pancolitis.129 The TLR2-R753Q mediates IEC dysfunction, failing to induce TFF3 synthesis in goblet cells17 and inhibiting GJIC through loss of Cx43 in enterocytes,102 which impairs restitution during wound healing. This evidence concerns the gene TLR2 and pancolitis.