APC and adenoma: A possible indirect link between MyD88 and the tumor suppressor gene APC has recently been reported.199 MyD88 null mice that also carry a germline mutation in the APC gene exhibited regression of spontaneous development of pretumoric adenomas, however, predominantly in the small intestine, which argues against a primary role of TLR signaling in the ApcMin/+ tumor model, as the bacterial load is normally very low in this part of the gastrointestinal tract.