MAPT and Alzheimer disease: Recently, a triple transgenic mouse (3xTg-AD) harboring the human APPSwe, PS1M146V, and TauP301L gene mutations was developed, displaying accumulation of both intracellular Aβ  and tau in an age-dependent manner within the cortex, hippocampus, and amygdala [11–14], and to a lesser degree, in the brainstem [15].