Recently a large multicenter study assessed the diagnostic value of the 42 amino acid long form of Aβ (Aβ42), total tau (T-tau), and tau phosphorylated at threonine 181 (P-tau181) in identifying subjects with incipient AD among patients with mild cognitive impairment (MCI) and they were found to provide good accuracy [10]. The gene discussed is MAPT; the disease is Cognitive impairment.