Consequently, both allele and genotype distributions were significantly different between a-MCI and mcd-MCI (allele: P = .02, genotype: P < .05).These results support the theory that polymorphisms of cytokine genes can affect neurodegeneration and its clinical progression.IL-10 may partly explain the conversion of a-MCI to AD or be a genetic marker of susceptibility. This evidence concerns the gene IL10 and Alzheimer disease.