GHRL and polycystic ovary syndrome: An additional study by Moran et al. revealed a dysregulation of ghrelin homeostasis in overweight women with polycystic ovary syndrome (PCOS), suggesting that women with PCOS exhibit similar ghrelin abnormalities with obese women (down-regulated fasting ghrelin, blunted postprandial ghrelin suppression), and this disorder was not differentially affected by diet macronutrient composition [53].